What are the medications for
treating ADHD?
Stimulants
The most common medications for
treating ADHD are stimulants. Stimulants have been the longest in use for
treatment of ADHD, and have the most research studies on their effects.
Although some have been used on children as young as age 3, most are
recommended for age 6 or older. Long-term studies on the use of stimulants
for the treatment of ADHD lean toward the discontinuation during
adolescence, due to possible growth inhibition.
Stimulants for the treatment of ADHD
may be shorter or longer acting formulations. Short/intermediate acting
stimulants require dosages 2-3 times a day, while long acting stimulants
last 8-12 hours, and can be taken once a day, thus not requiring a dose at
school.
There are four main types of
stimulants used for treatment of ADHD:
- amphetamines (Adderall)
- methylphenidate (Ritalin, Concerta,
Metadate)
- dextroamphetamine (Dexedrine,
Dextrostat)
- pemoline (Cylert - less commonly
prescribed because can cause liver damage)
Non-stimulant
The newest medication for treatment of
ADHD is Strattera. This medication is a reuptake inhibitor that acts on
the neurotransmitter norepinephrine (which affects blood pressure and
blood flow) in the same way that antidepressants act on the
neurotransmitter seratonin, allowing the natural chemical to remain longer
in the brain before being drawn back up. Because it is a non-stimulant, it
may be less objectionable to some families. Nevertheless, it has similar
side effects as other medications used for ADHD.
Antidepressants and anti-anxiety
medications
In some cases, antidepressants or
anti-anxiety medications may be prescribed either in addition to or
instead of stimulants for the treatment of ADHD. Most often, this
determination is based on other symptoms, beyond those typical of ADHD
alone. Antidepressants most commonly affect the neurotransmitters
seratonin or norepinephrine. There have been recent concerns regarding the
safety of some antidepressants, such as Paxil and Zoloft, particularly for
adolescents or children.
Antipsychotic or
mood-stabilizing medications
For certain conditions that include
symptoms of ADHD, other medications may be prescribed. With a few
exceptions for seizure disorders, antipsychotic medications are not
prescribed for children and most mood stabilizers are not recommended for
children or adolescents.
What are some of the side
effects of medications for ADHD?
Side effects most commonly
include:
- decreased appetite or weight loss
- headaches
- upset stomach, nausea or vomiting
- insomnia or sleep difficulties
- jitteriness, nervousness, or
irritability
- lethargy, dizziness, or drowsiness
- social withdrawal
All medications have side effects, and
sometimes a change in dosage, brand or type of medication will allow for
the usefulness of the medication while reducing the side effects. One
problem with medications for ADHD is that they are most often prescribed
for young children, who usually will not be able to accurately report side
effects. This is one of the concerns about prescribing any medications for
children.
What is the role of medications
in the treatment of ADD in adults?
Some of the newer medications are
touted for their use with adults, and some of the well-known authors of
books on ADHD have found that Ritalin, Strattera, or other drugs have been
helpful to them. However, all drugs should be approached with caution, as
they have side effects that may prove to be more difficult than the
problem they are supposed to be treating, and new cautions are added as
studies indicate additional difficulties (see Strattera warning in box
above). For those who decide to try medications, it is wise to:
- Educate yourself thoroughly about
the drugs available, the potential side effects, and any interactions
with other medications you take.
- Follow directions closely, starting
with a very small dose and increasing gradually, according to the
doctor’s schedule.
- Pay attention to your body,
emotions, and actions to determine if any negative side effects are
occurring.
- Ask your doctor for specific
instructions for decreasing and/or terminating use – these drugs need to
be tapered off, not stopped suddenly.
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How do antidepressants work?
People suffering from depression are
thought to have lower levels of some of the chemical messengers in the
brain, called
neurotransmitters. The three neurotransmitters believed to be involved
in depression are
serotonin, dopamine, and norepinephrine. Neurons in the brain
constantly produce, release, and reabsorb these brain chemicals.
Antidepressants increase the levels of these neurotransmitters in the
brain by blocking their reabsorption.
While this has led to the popular belief that depression is the result of
a
chemical imbalance in the brain that can be corrected with drugs, the
reality is more complex. It is not yet known whether low levels of
neurotransmitters cause depression, or whether depression causes this
imbalance in brain chemistry.
How effective is medication for
depression?
While antidepressants provide relief for
some people, they are not a “magic bullet” for depression. Antidepressants
reduce symptoms in approximately 70 percent of people. This leaves nearly
1 out of 3 people who don't get relief. Even in those who respond to
medication, complete remission is rare. More commonly, their symptoms are
reduced but not cured.
Medication vs. Therapy
While antidepressants may improve mood by
boosting the “feel-good” chemicals in your brain, they don't treat the
actual cause of the depression. Because of this, relapse rates are high
once drug treatment is stopped. In contrast, the emotional insights and
coping skills acquired during therapy can have a more lasting effect on
depression. A
University of Pennsylvania study backs up this claim. It found that
cognitive therapy works just as well as antidepressants and is more
effective than medication in preventing relapse once treatment ends.
In a moderate to severe depression,
medications may be useful in the short term, but should be accompanied by
therapy to address underlying issues. Sometimes the heaviness of a
depression serves to mask painful emotions, which may then come to the
surface when medications are taken. The result can be an unexpected
sadness – yet another reason that psychotherapy is so important when using
antidepressants.
Can antidepressants make depression
worse?
There is a risk that antidepressant
treatment will cause an increase, rather than a decrease, in depression.
In fact, all depression medications are required by the FDA to carry a
warning about the increased risk of suicide, hostility, and agitation.
****FDA Suicide Warning****
In a 2005
Public Health Advisory, the FDA advises that anyone on
antidepressants should be watched for increases in suicidal thoughts and
behaviors. Monitoring is especially important if this is the person’s
first time on depression medication or if the dose has recently been
changed. If the depression appears to be getting worse, an evaluation by
a mental health professional should be scheduled as soon as possible.
What can happen when you stop taking
antidepressants?
If you abruptly stop taking your
antidepressant medication, you may experience a number of unpleasant
withdrawal symptoms such as dizziness, nausea, lethargy, and headache.
This is known as
Antidepressant Discontinuation Syndrome. Antidepressant
discontinuation syndrome is especially common when you stop taking Paxil
or Zoloft. However, all medications for depression can cause withdrawal
symptoms.
Antidepressant Withdrawal Symptoms:
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|
Emotional symptoms: |
- Agitation
- Crying
- spells
- Irritability
- Anxiety
- Aggression and impulsive behavior
Depersonalization
- Memory problems
- Confusion
- Lowered mood
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|
Flu-like symptoms: |
- Fatigue
- Headache
- Muscle aches
- Weakness
- Sweating
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Gastrointestinal: |
- Nausea and vomiting
- Abdominal pain or cramping
- Loss of appetite
- Diarrhea
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Sleep disturbance: |
- Insomnia
- Nightmares
- Vivid dreams
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Balance: |
- Dizziness
- Lightheadedness
- Vertigo
- Clumsiness
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Sensory disturbances: |
- Numbness
- Blurred vision
- Tingling sensation
- Electric shock sensations
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Movement: |
- Tremor
- Muscle twitches and jerks
- Muscle stiffness
- Loss of coordination
- Inability to sit still
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Depression and anxiety are common
symptoms when withdrawing from antidepressants. When depression is a
withdrawal symptom, it is often more severe than the original depression
that led to drug treatment. Unfortunately, many people mistake this
withdrawal symptom for a return of their depressive illness and resume
medication, creating a vicious circle.
In order to avoid antidepressant
withdrawal symptoms, never stop your medication “cold turkey.” Instead,
gradually taper your dose, allowing for at least 1-2 weeks between each
dosage reduction. This tapering process may take up to several months, and
should be monitored under a doctor's supervision.
How do I decide whether antidepressants
are right for me?
If you are considering antidepressants as
a treatment option, here are some questions that should help you make your
decision:
Questions to ask yourself and a mental health professional
- Is my depression severe enough to
justify drug treatment?
- Is medication the best option for
treating my depression?
- Am I willing to tolerate unwanted side
effects?
- What non-drug treatments might help my
depression?
- Do I have the time and motivation to
pursue other treatments such as psychotherapy and exercise?
- What self-help strategies might help
reduce my depression?
- If I decide to take medication, should
I pursue psychotherapy as well?
Questions to ask your doctor
- Are there any medical conditions that
could be causing my depression?
- What are the side effects and risks of
the antidepressant you are recommending?
- Are there any foods or other
substances I will need to avoid?
- How will this drug interact with my
other prescriptions?
- How long will I have to take this
medication?
- Will withdrawing from the drug be
difficult?
- Will my depression return when I stop
taking medication?
What guidelines should I follow if I
decide to take antidepressants?
If you decide that treating your
depression with medication is the right option, you will need to see a
doctor. The first guideline is to consult with a psychiatrist, rather than
your family physician. Although any medical doctor can prescribe
medications, psychiatrists are doctors who specialize in mental health
treatment. They are more likely to be familiar with the newest research on
antidepressant medication and to know about specific safety concerns. Your
health and well-being depend on your doctor's expertise, so it's important
to choose the physician who is best qualified.
You should also educate yourself about
your drug. Make sure you know about its common side effects and any
special warnings. For more information about minimizing the risks of
prescription drug treatment, visit
10 Rules for Safer Drug Use. Print out the included
Drug Worksheet and bring it to your doctor. Your doctor can fill out
instructions on how and when to take the drug, what adverse reactions to
look out for, and possible food and drug interactions. You can also use
the worksheet to keep track of how you're responding to the
antidepressant.
Here are some other guidelines:
- Be patient – Finding
the right drug and dosage is a trial and error process. It takes
approximately 4 to 6 weeks for antidepressant medications to reach their
full therapeutic effect. Many people try several medications before
finding one that works for them.
- Follow instructions –
Be sure to take your antidepressant according to the doctor's
instructions. Don't skip or alter your dose, and don't stop taking your
pills as soon as you begin to feel better. Stopping treatment
prematurely is associated with high relapse rates.
- Monitor side effects
– Keep track of any physical and emotional changes you’re experiencing
and talk to your doctor about them. Contact your doctor or therapist
immediately if your depression gets worse or you experience an increase
in suicidal thoughts,
- Go to therapy –
Medication can reduce the symptoms of depression, but it doesn’t treat
the underlying problems. Psychotherapy can help you get to the root of
your problems, change negative thinking patterns, and learn new ways of
coping.
What are the types of antidepressants
and what are their side effects?
SSRIs (selective serotonin reuptake
inhibitors)
SSRIs act on a chemical in the brain
called serotonin. They are the most commonly prescribed class of
antidepressants because the adverse effects are less severe than those of
older antidepressants. Common side effects include nausea, drowsiness,
sexual dysfunction, and agitation. The SSRIs also cause serious withdrawal
symptoms if you stop taking them abruptly.
| SELECTIVE SEROTONIN
REUPTAKE INHIBITORS (SSRIs) |
| Generic
and Brand Drug Names |
|
|
|
| Most
Common Side Effects |
- Nausea
- Insomnia
- Anxiety and restlessness
- Decreased sex drive
- Dizziness
- Weight gain or weight loss
|
- Tremors
- Sweating
- Drowsiness or fatigue
- Dry mouth
- Diarrhea or constipation
- Headaches
|
| Other
precautions & warnings |
|
SSRIs can cause
an increase in suicidal thoughts and behaviors. SSRIs also carry a
risk for increased hostility, agitation, and anxiety. SSRIs should not
be taken at the same time as MAOIs. Taking an SSRI within two weeks of
an MAOI can cause a fatal reaction. |
| For
further information |
SSRIs – Harvard Medical School
Antidepressant Discontinuation Syndrome
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Tricyclic antidepressants
Tricyclics are an older class of
antidepressants than the SSRIs. The tricyclics typically take around two
weeks to provide symptom relief. They have many side effects, including
weight gain and drowsiness. Drowsiness is particularly common in the first
few weeks after starting the medication. The tricyclics can cause many
withdrawal symptoms when discontinued abruptly.
MAOIs (Monoamine oxidase inhibitors)
MAOIs are the oldest class of
antidepressants. Common side effects include weight gain, dizziness,
drowsiness, and loss of sex drive. MAOIs also have severe interactions
with certain foods, drinks, and medications. If you choose to take an MAOI,
you will have to carefully monitor what you eat and what drugs you take.
Items that are restricted include many cheeses, chocolate, wine, and beer.
For a more complete guide, read
MAOI Diet Facts. If you have previously taken an SSRI, you should wait
at least five weeks before taking an MAOI. Combining SSRIs and MAOIs can
lead to a life-threatening condition called
serotonin syndrome.
| MONOAMINE
OXIDASE INHIBITORS (MAOIs) |
| Generic
and Brand Drug Names |
|
|
|
| Most
Common Side Effects |
- Lightheadedness upon standing
- Dizziness
- Insomnia
- Weight gain
|
- Headaches
- Insomnia
- Sexual problems such as impotence
- Sleepiness
|
| Other
precautions & warnings |
|
When taking an
MAOI, you must follow strict dietary restrictions, avoiding all foods
and drinks containing tyramine. Combining MAO inhibitors with foods or
drinks containing tyramine can cause dangerously high blood pressure,
which can lead to a stroke or heart attack. |
Atypical antidepressants
There are a variety of newer atypical
antidepressants which target other neurotransmitters either alone or in
addition to serotonin. Some of the brain chemicals they affect include
norepinephrine and dopamine. The side effects vary according to the
specific drug.
| ATYPICAL
ANTIDEPRESSANTS |
|
Generic and Brand Drug Names |
|
|
|
|
Most Common Side Effects |
- Nausea
- Nervousness
- Sexual dysfunction
- Dry mouth
|
- Fatigue
- Sleepiness
- Weight gain
- Blurred vision
|
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